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Individuals at higher risk include older adults with reduced stomach acid production, people with gastrointestinal conditions affecting absorption, strict vegans, and those taking medications like metformin or proton pump inhibitors

176 In 1928, it was demonstrated by Zunc and LaBarre that the injection of secretin, which is extracted from the small intestinal mucosa, shows a hypoglycaemic effect that is mediated by the pancreas

No direct pharmacological link exists between GLP-1/GIP medicines and B12 deficiency, but concurrent metformin use (common in diabetes) is established to reduce B12 absorption

Cock, P

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