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In control experiments, both native GLP1 and GLP1(936) have been shown to produce vasodilation and increase cGMP release from isolated, preconstricted blood vessels when tested ex vivo

But its really about how valuable a reward feels. Physician Spencer Nadolsky, an obesity specialist whose large online following gives him an unusually broad window into patient experience, said he began hearing reports from patients on GLP-1s of a subtle loss of motivation about a year and a half ago

doi:10.1007/s003940200001

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