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Activation of Glucagon-like Peptide-1 Receptor Inhibits Tumourigenicity and Metastasis of Human Pancreatic Cancer Cells via PI3K/Akt Pathway

Eggers test revealed significant publication bias for some outcomes at three months, with no evidence of bias for most outcomes at other time points

Dosing Comparison# Retatrutide Dosing# Based on Phase 2 trial data: Route : Once-weekly subcutaneous injection Dose range studied : 0.5 mg to 12 mg weekly Optimal dose : 12 mg weekly showed maximum efficacy in Phase 2 Titration : Gradual dose escalation over several weeks to manage GI tolerability Tirzepatide Dosing# Established FDA-approved dosing: Route : Once-weekly subcutaneous injection Starting dose : 2.5 mg weekly for 4 weeks Maintenance range : 5 mg, 10 mg, or 15 mg weekly Titration : 2.5 mg increments every 4 weeks to target dose Available formulations : Prefilled pens (Mounjaro/Zepbound) Tirzepatide's established titration protocol and prefilled pen delivery system offer practical advantages in clinical use

Journal of nuclear medicine : Official publication, Society of Nuclear Medicine, 60(6), 858-863

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