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Cognitive function tends to improve the longer a person abstains from drug use [173, 180]

FIGURE 5 4.6 Delayed gastric emptying GLP-1RAs has been shown to delay gastric emptying (Jelsing et al., 2012), thereby extending the retention of food in the stomach and small intestine and reducing postprandial glucose levels (Winkler et al., 2019)

doi: 10.1016/j.beem.2004.03.003 55 KrassasGEPoppeKGlinoerD

And it diverts blood flow away from salivary glands toward working muscles, temporarily reducing saliva production even in people with normal salivary function

According to this rule, drug molecules having more than five hydrogen bond donors, more than 10 hydrogen bond acceptor, logP more than five and molecular weight more 500 dalton are less likely to be orally active