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The expression of PGC1 and OXPHOS activities are increased in the long-living Ames dwarf mice (lack of GH, prolactin, and thyroid-stimulating hormone), demonstrating a negative effect of GH on mitochondrial biogenesis (Westbrook et al., 2009
Studies examining links between TB500 and integrin linked kinase suggest potential involvement in pathways related to cell adhesion, structural organization, and communication between cells and their surrounding matrix
This is significant because age-related sleep disruption often involves not just melatonin deficiency but broader circadian gene dysfunction
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We're starting with a fundamental one
