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Both bind the GHS-R1a ghrelin receptor
Zahid, A
The D-isomer is more specific for DA transmission and is a better stimulant compound
In this case, the diminished affinities of the D-Ala analogues relative to the natural agonists could be compensated by an increase in average number of G proteins activated to cause the observed similarity in receptor activation efficacies of the D-Ala analogues relative to GLP-1 and exendin-4
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