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Individuals with severe B12 deficiency benefit most from IV infusions because intravenous delivery raises serum levels faster than other supplementation routes
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But for most purposes (like weekly maintenance injections), IM is the preferred route at home because its simpler (the vitamins absorb quickly from muscle into the bloodstream over a few hours)
In other words, subjects will likely need a higher dose of intranasal spray to achieve comparable results to injections
