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IGF-1 is a growth factor, and chronically elevated levels carry theoretical concerns about promoting the growth of pre-existing neoplasms
An intracellularly expressed single-chain variable fragment targeting mitochondrial CD147 (mito-CD147 scFv) effectively disrupts the mitochondrial CD147/MCT1/LDHB complex, inhibits lactate-induced stemness potential, depletes circulating breast cancer cells, and reduces metastatic burden, suggesting promising clinical applications in reducing lactate-fueled metastasis
i.e., quick progressive (spermatozoa moved quickly in a linear way), slow progressive (spermatozoa moved slowly in a linear way), non-progressive (spermatozoa showed circular movements), and immotile (spermatozoa had no circular and linear movements)
Peptide YY(136) and peptide YY(336): part i
Bottom: volcano plot showing relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from ER-tag HEK293T cells treated with thapsigargin compared to untreated
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