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Among these symptoms, lipid peroxidation is evident throughout the progression of DN, and the levels of the products of lipid peroxidation, namely, MDA and 8-iso-PGF2 can be indicators to judge or predict the degree of kidney injury in the early stage of DN

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[3] The doses used in these tendon studies typically ranged from 10 to 200 micrograms per kilogram of body weight, administered once daily, which when extrapolated to a 75-kilogram human would suggest a working range of approximately 200 to 500 micrograms per day

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