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For tirzepatide, because the 5-day half-life is shorter than the 7-day dosing interval, moderate accumulation occurs with each successive injection until this balance is reached typically after 4 to 5 weeks [2]

First, cash-pay patients would have a meaningfully lower-cost option

Noack R et al

Cytokine levels were measured using enzyme-linked immunosorbent (ELISA) assay kits: Human 1L-10 ELISA Ready-SET-Go from Affymetrix (Cat# 88-7106) and Human TNF- Uncoated ELISA (Cat # 88-7346), Human IFN- Uncoated ELISA (Cat # 88-7316), and Human IL-6 Uncoated ELISA (Cat # 88-7066) from Invitrogen to quantity detection of cytokines

Daly FF, Fountain JS, Murray L, Graudins A, Buckley NA