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Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization

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When comparing ipamorelin vs sermorelin, ipamorelin acts on the ghrelin receptor (GHS-R1a) with high selectivity, producing a GH pulse without affecting cortisol or appetite hormones

Decreased body fat: increases fat metabolism which can lead to overall improvements in body composition

Thyroid concerns exist for GLP-1 agonists due to findings in rodent studies showing C-cell hyperplasia and medullary thyroid carcinoma