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HIF-1 is activated due to blockade of its degradation pathway mediated by low oxygen levels, thereby increasing the expression of target genes, including those encoding glycolytic enzymes and glucose transporters, and increasing lactate secretion 67

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The very tissue that keeps your metabolism humming, protects your joints, helps you climb stairs at 70, and determines whether weight loss transforms your health or just makes you a smaller, weaker version of yourself

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