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In secondary, intention-to-treat analyses, participants were followed from the index date to first SIS event, death, or end of follow-up, and were analysed according to the treatment assigned at baseline, irrespective of actual exposure during follow-up

Should be preferred: Applied when at least one Phase III randomized controlled trial with prespecified, phenotype-specific primary endpoints demonstrated clinically meaningful benefit, with regulatory approval and no major safety concerns

Serious but rare adverse effects: Whilst uncommon, several serious adverse effects require awareness

Non-Exercise activity thermogenesis in human energy homeostasis