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J Clin Invest 123(9):36783684 Herranz D, Ambesi-Impiombato A, Sudderth J et al (2015) Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

This is especially important because the wrong response to side effects can create a downward spiral: nausea leads to under-eating under-eating leads to weakness and poor protein intake poor intake and GI symptoms contribute to dehydration exercise tolerance drops patients lose weight, but not in a healthy or durable way A supervised plan helps interrupt that pattern early

Emphasis is placed on the use of antioxidants such as vitamins C and E, omega-3 fatty acids, and Zn

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Called Byetta (exenatide) and originally developed by Amylin Pharmaceuticals, the drug was later marketed by AstraZeneca