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Monitoring strategies include periodic assessment of treatment response, adjustment of protocols based on outcomes, and long-term maintenance planning
The PZQ plasma exposure, measured by C max , is substantially lower than the LD 50 against adult worms and NTS reported by others 61,62 , and substantially below the LD 50 for NTS killing measured herein (2743 M)
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We believe that one of the important mechanisms underlying this effect is likely reduction of inflammation in the fatty tissue around the heart, which we know is an important driver of arrhythmias and other unwanted cardiac outcomes. Bilchick plans to continue investigating these inflammatory mechanisms in collaboration with UVA immunology researcher Coleen McNamara, UVA MRI physicist Frederick Epstein (who developed an MRI method to characterize fatty tissue surrounding the heart), and UVA Director of Cardiac Imaging Amit Patel
Henry Gregg, chief executive of the National Pharmacy Association, described the guidance as game changing and called for community pharmacy to be used in the deployment of weight-loss medication
