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And retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, showed remarkable weight loss results in clinical trials

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Additional considerations include diabetic retinopathy status (semaglutide may worsen retinopathy in some patients with pre-existing disease, particularly with rapid A1c improvement), history of pancreatitis (use GLP-1 agents with caution), and upcoming surgical procedures (discuss with your surgical/anesthesia team due to effects on gastric emptying)