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[6] [7] Pharmacology [edit] Mechanism of action [edit] Metadoxine is a selective antagonist of the serotonin receptor subtype 5-HT 2B [8] and displays high affinity to the gamma-aminobutyric acid (GABA) transporter

More importantly, the synthesis of SAM, which requires the folate cycle, is crucial in neuropsychiatry for its role as a therapeutic agent in the treatment of depression, and as an antidepressant in Parkinsons disease (30, 65, 67)

PTGS2, prostaglandin-endoperoxide synthase 2

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