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Each dose escalation restarts the four-to-five-week steady-state clock, which is why the full therapeutic effect takes several months to emerge

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Supporting this compartmentalized energy strategy, synaptic mitochondria have been shown to express lower levels of OXPHOS subunits and calcium-buffering proteins than their non-synaptic counterparts, indicating limiting oxidative capacity and highlighting the importance of glycolytic ATP production at the synapse [63]

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