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intravenous TB-4 Phase 1 safety and pharmacokinetics, no dose-limiting or serious adverse events (Ann N Y Acad Sci 2010;1194:223229): NCT00743769 Centers for Disease Control and Prevention

These metabolites make up 5-8% and 2% of the renally excreted dose with 87-90% appearing as unchanged drug

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MOTS-c dosing in clinical settings is based on extrapolation from mouse pharmacology (5 mg/kg in mice, allometrically scaled)

Growth hormone secretagogues like ipamorelin enhance systemic anabolic signaling that supports tissue repair