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He said Roches well-timed move follows the coattails of the successes achieved by GLP-1 agonists like Ozempic, Wegovy, Mounjaro and Zepbound
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The GIP receptor activation adds metabolic effects that pure GLP-1 agonists do not provide, including potential benefits for bone formation and gut motility that may actually buffer against certain gastrointestinal side effects
The signaling pathways in the GIT includes the complex enteric nervous system (ENS) that consist of two neural networks located in the submucosa layer and has pacemaker cells and controls i.e., motility via release of neurotransmitters based on the amino acid tryptophan associated neurotransmitter serotonin (5-HT: Serotonin, 5-hydroxytryptamine), dopamine and GABA
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