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Several publications note BPA is an ER agonist that induces ERE-mediated transcriptional activation of esr1 14,22

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Stier et al., Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans, Journal of Endocrinology and Metabolism, 2013

Downregulation of GSTM3 increased the cell proliferation capacity compared to shNC in PANC-1 stable cell lines (Figure 3A)

Berberine activates AMPK through a different mechanism than MOTS-c (via inhibition of complex I in mitochondria), so concurrent use may create additive rather than synergistic AMPK activationhigher risk of hypoglycemia without proportional metabolic benefit