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If youre not losing weight in a calorie deficit, it may be due to underlying factors that make progress harder

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Elevated cortisol levels increase gluconeogenesis in the liver, impair insulins ability to translocate GLUT4 to the cell surface, and raise portal and peripheral free fatty acids [72, 73]

While mild at first, continued nausea indicates worsening toxicity, requiring emergency care to prevent progression to liver damage

The study found that patients on GLP-1 agonists experienced a 35% reduction in myocardial infarctions compared to the matched control group, along with a 22% reduction in ischemic strokes and an 18% reduction in heart failure exacerbations