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However, when combination with HDAC4 (or HDAC5) with HDAC3, the transcriptional repression is facilitated via simultaneous binding of silencing mediator for retinoid and thyroid receptors (SMRT) and nuclear receptor corepressor (N-CoR) [63, 64]
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And when regulation becomes harder to maintain, the body begins to reach for compensatory mechanisms strategies that temporarily soothe, anchor, or stimulate the system
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