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One major limitation is the incomplete knowledge of the metabolic pathways and transformations that polyphenols undergo after ingestion, particularly due to interactions with the gut microbiome and the formation of diverse metabolites whose biological activities are not well characterized (119)

Combination effects with other supplements LC or ALC has not only been supplemented individually, in many experiments researchers have supplemented it in combination with other nutrients [20, 21, 44, 83,84,85,86,87,88] (Table 3)

Curr Med Res Opin 1990;11:638-47

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