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This report used metabolomic analyses with selected metabolites in the tryptophan, tyrosine, purine, tocopherol, and the related pathways in a sample of nonpsychotic depressed outpatients who were treated for 8 weeks with citalopram or escitalopram to address the following questions: The metabolomic signature of exposure to escitalopram/citalopram: which metabolite changes occurred from baseline to week 4, and from baseline to week 8 of treatment