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A protective effect of GLP-1 agonists on blood vessels has been demonstrated, as evidenced by the reduction of non-fatal and fatal stroke incidence by 15% and 19%, respectively, in patients with T2DM treated with GLP-1 agonists [43]
Notably, it can potentially affect the efficacy or side-effect profile of drugs such as nitroglycerin, nitrates, and some chemotherapy agents
The FTO rs9939609 variant, for example, is associated with increased hunger drive and may influence how much semaglutide benefit you experience over time
Lancet Diabetes Endocrinol 8(5):392406 Yabe D, et al (2024) PIONEER REAL Japan: primary results from a multicenter, prospective, real-world study of oral semaglutide in adults with type 2 diabetes in Japanese clinical practice
ICAM 1, intercellular adhesion molecule 1
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