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While compounds 6 - 8 caused maximal inhibition of TGR within 15 min (referred to here as fast inhibitors
Switching between GLP-1 medications needs care because doses are not directly interchangeable
These include type 2 diabetes, high blood pressure, cardiovascular disease, and obstructive sleep apnoea
These toxicities often necessitate dose reduction or premature discontinuation of chemotherapy regimens
However, when combined with insulin or sulfonylureas, the risk of low blood sugar increases significantly, requiring careful monitoring and possible dose adjustments of those medications
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