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doi: 10.1016/J.FOODCHEM.2023.138164 101 HanJ.LinC.ZhuT.LiuY.YanJ.QiZ.et al
High dose intravenous (IV) thiamine supplementation (500 mg thiamin dissolved in 100 mL normal saline) led to a reduction in the frequency of migraine attacks ( Mitochondrial dysfunction theory is one of the hypotheses related to thiamine-migraine association ( Riboflavin Riboflavin is one of the most essential vitamins B due to its properties, such as anti-inflammatory, antioxidant, anti-nociceptive, and anti-aging ( Disruption in brain energy metabolism is considered a proposed cause of migraine attacks ( A randomized clinical trial (RCT) demonstrated that high-dose riboflavin supplementation (400 mg/d) could decrease the attack frequency, duration, severity, and number of headache days in adults with migraine, after 3 months
(The third, Foundayo, just got FDA approval in April, so its too new for spending data.) In 2024, Medicare spent over $19.3 billion on Ozempic and Mounjaro, according to gross spending data from CMS
LyssenkoVEliassonLKotovaOPilgaardKWierupNSalehiAet al
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