Numerous preclinical reports have highlighted the ability of curcumin to restore reduced GSH levels and the activities of GSH-related antioxidant enzymes in the myocardium after exposure to cardiotoxic factors, for example, DOX, I/R, diabetes, hyperthyroid conditions, and copper sulfate [184,185,186,187,188]
Food and Drug Administration (FDA) for any medical application
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This process requires the involvement of protein disulfide isomerase (PDI), ER redox protein 1 (ERO1), and GRP78 chaperone protein