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Reconstituted: 28 days
It covers more pathways than CagriSema (which is missing GIP) but fewer than cag + retatrutide (which adds glucagon)
evaluate full protocol at week 12 vs
This is one reason why in vitro findings require careful translation into preclinical tissue-level models
The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study
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