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The peptide's actin-sequestering activity proves particularly important for endothelial cell migration, with studies showing TB-500 significantly enhances endothelial cell migration rates and tube formation in angiogenesis assays while promoting the formation of stable, mature blood vessels with appropriate pericyte coverage

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They operate through non-overlapping mechanisms and are commonly combined in longevity protocols

doi: 10.1002/14651858.CD001301.pub2 224 ArhinSKZhaoYLuXChetryMLuJ