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In contrast, one research trial using GLP-1 drugs on obese research subjects did not show a benefit from GLP-1 in the prevention of depression, anxiety, and suicidal behavior (Kornelius, 20240)
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GLP-1 receptor agonists work in part by slowing gastric emptying, which is what prolongs fullness and reduces appetite
By contrast, the use of sodium-glucose cotransporter 2 inhibitors is associated with a lower incidence of epilepsy (97)
But they work through different pathways, target different outcomes, and suit different patient profiles
Or still considered investigational
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