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Factors that extend the waiting period Several situations warrant waiting longer than the standard timeline: Postpartum hemorrhage or significant blood loss during delivery Preeclampsia or pregnancy-induced hypertension that has not fully resolved Active postpartum depression or anxiety that is not yet stabilized with treatment Difficulty establishing breastfeeding or low milk supply concerns Ongoing wound complications from C-section or perineal repair History of eating disorders, which GLP-1 appetite suppression could trigger Significant nutritional deficiencies identified in postpartum blood work, particularly iron deficiency anemia The American College of Obstetricians and Gynecologists has not yet issued specific guidelines on postpartum GLP-1 use, which means decisions are being made on a case-by-case basis between patients and their providers

FBW7, a substrate-recognition component of the SCF ubiquitin ligase complex, inhibits the transcription of SCD1 by antagonizing the transcription factor NR4A1, which subsequently decreases MUFA generation from SFAs and reverses resistance to ferroptosis

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Among the 1,127 participants with prediabetes at baseline in the ATTAIN-1 trial, up to 91% of those taking orforglipron achieved normoglycemia (normal blood sugar levels) at 72 weeks, compared with only 42% of those taking placebo