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Nurx 3-in-1 Pill (Naltrexone HCl 5 mg/Bupropion HCl 50 mg/Metformin HCl 250 mg capsule), an Rx only compound drug, has not been FDA-approved or evaluated for safety, efficacy, or quality but can be used to reduce hunger and appetite and promote weight loss

As tirzepatide was compared to controls, the hazard ratios for MACE-4 were 0.80 (95% confidence interval [CI], 0.571.11), cardiovascular death was 0.90 (95% CI, 0.501.61), and all-cause death was 0.80 (95% CI, 0.511.25) [2]

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The American Gastroenterological Association (AGA) released a clinical practice update and found insufficient data to support patients stopping GLP-1 medication prior to elective endoscopy procedures

These compounded versions differ from FDA-approved medications: They bypass the strict FDA new drug approval process and are not reviewed by the FDA for safety, efficacy, or manufacturing quality