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Unblinding Unblinding of the participants will be permissible under the following circumstances: treatment of a participant in a medical emergency that requires knowledge of treatment allocation, treatment of a participant for an adverse event (AE), in the event of a suspected unexpected serious adverse reaction (SAR), and SAR is defined as any untoward medical occurrence that results in death, is life-threatening, requires hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity or is a congenital anomaly or birth defect

SURMOUNT-1: the landmark trial SURMOUNT-1 enrolled 2,539 adults with obesity or overweight, with at least one weight-related complication, but without type 2 diabetes

Rybelsus requires strict fasting instructions because it uses oral semaglutide technology

However, if you are taking warfarin or other coumarin anticoagulants, more frequent INR monitoring may be advisable when starting or adjusting Ozempic

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