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Notably, there was no evidence that time-varying weight loss mediated the effect of semaglutide on MACE
In head-to-head comparison during the STEP trials, semaglutide 2.4 mg weekly produced significantly greater weight reduction than liraglutide 3.0 mg daily, approximately 15% versus 7% of body weight over similar timeframes
Drugs without GIPR activity (semaglutide, orforglipron, survodutide, pemvidutide) are plotted along the bottom axis
Some people prefer to take it in the evening to sleep through the initial hours of potential side effects
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