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Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance (STEP 4) Wadden et al
GLP-1s open a new era: clinicians must guide it with timeless tools, nutrition, exercise, education, renewed by science and technology
29 Nonrandomized reports across a spectrum of HF (ambulatory patients with chronic HF, a new HF diagnosis, and individuals with a recent hospitalization) and a variety of ages do not support harm with metformin therapy, though metformin is contraindicated in decompensated HF
However in type 2 diabetes, B cell glucose metabolism is dysfunctional, resulting in elevated blood glucose levels
It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability
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