3 But biotechnology and pharmaceutical companies dont have to navigate the drug development journey alone
Even when higher doses up to 2,000 mg/day, no adverse reactions have been observed (22, 23) On the other hand, dietary fiber is used by some bacteria in the gut microbiota for butyrate production in two different ways: (I) Direct, where fiber acts as a substrate for bacterial fermentation producing butyrate, (II) Indirect since bifidogenic fibers help to increase the abundance of bifidobacteria, which increase butyrate production indirectly (24)
In parallel, companies are exploring non-GLP-1 approaches (ghrelin antagonists, amylin analogs like cagrilintide, FGF21 analogs, GDF15 agonists) to complement or challenge the GLP-1 paradigm
Side effects are the biggest concern Among people who have never used GLP-1 injections, side effects were the most commonly selected reason for not pursuing treatment, with almost a quarter of people we spoke to ( 24.45% ) saying they put them off
Average weight loss was ~2 kg (a bit less than liraglutide or semaglutide, but more than albiglutide)