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Glucagon receptor activation: Increases hepatic glucose output (relevant in fasted states), stimulates lipolysis in adipose tissue, and raises basal metabolic rate through thermogenic mechanisms

This isn't just a case of two things being generally 'unhealthy.' It's a direct, antagonistic interaction on a physiological level

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The amount of calories you require is determined by your existing weight, level of activity, metabolic rate, and objectives for shedding pounds

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