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However, it remains unclear whether these natriuretic responses are direct effects of GLP-1RA because a lack of GLP-1R in the proximal tubules has been reported (Ronn et al., 2017)
This conservative starting approach allows patients to adapt to the medication and helps identify any early adverse reactions
Clinical trials show that patients who follow a gradual escalation schedule report better tolerability and higher medication adherence than those who jump to higher doses immediately
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