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[1] [2] As of 20242025, retatrutide remains under clinical investigation and has not been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom, nor by the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA) for routine clinical use

The article on how long compounded semaglutide lasts in the fridge discusses stability timelines in detail, and the question of does compounded semaglutide need to be refrigerated has a definitive answer: yes, always