Pay in 4 interest-free payments of $5.96 Learn more
Ships within 48 hours · Estimated delivery Aug 21 - Aug 26
Gastrointestinal symptoms dominated the safety profile, with nausea affecting up to 25% of patients at the highest doses, while rash or itching-related dermatological events were reported in fewer than 3% of participants and were generally mild
After removing duplicates and carefully selecting titles and abstracts for relevance, 112 full-text articles were reviewed in detail
Sensitivity analysis demonstrated variations in the pooled effect size of HbA1c changes, ranging from 1.30 (95% CI: 0.372.98
,
The chromatographic ion exchange resin is chosen depending on the specific GLP-1 peptide to be purified and the conditions employed, such as pH, buffer, ionic strength etc., which are known to the person skilled in the art (that is, typically, pH below the isoelectric point (pl) of the GLP-1 peptide for cation exchange resins and pH above pl of the GLP-1 peptide for anion exchange resins, a sufficient buffer strength to maintain the desired pH, and a sufficiently low ionic strength possibly induced by the salt concentration), and includes but is not limited to Sepharose resins, Sephadex resins, Streamline resins, and Source resins from Amersham-Pharmacia Biotech, HyperD resins, Trisacryl resins, and Spherosil resins from BioSepra, TSKgel resins and Toyopearl resins from TosoHaas, Fractogel EMD resins from Merck, Poros resins from Perseptive Biosystems, Macro-Prep resins from BioRAD, Express-ion resins from Whatman etc
