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The authors elucidated a mechanism wherein MCT1-mediated lactate uptake promotes ATP production, leading to AMPK deactivation and subsequent upregulation of SREBP1 and SCD1, enhancing the production of MUFAs that confer protection against ferroptosis (57)
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While MR analysis provides valuable insights into potential causal relationships from real-world data, the complexity and variability inherent in such data also pose limitations, making it challenging to control for all confounding variables
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