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No significant toxicity has been identified in animal studies even at doses far exceeding typical human protocols

Korean J Pediatr

Patients should stop the medication and contact their healthcare provider immediately if they experience: Severe or persistent abdominal pain (especially if radiating to the back), which could indicate pancreatitis Persistent vomiting preventing adequate fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) Yellowing of skin or eyes (jaundice) or pale stools Unexplained fever Severe diarrhoea lasting more than 48 hours Treatment continuation is reviewed regularly, with decisions based on efficacy, tolerability, and ongoing clinical need

Cushman, MD, professor of physical medicine and rehabilitation at the University of Utah Health

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