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GLP-1 Receptor Agonists, Obesity, and Cardiovascular Disease Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were originally developed to improve glycemic control in type 2 diabetes but have since demonstrated benefits in weight reduction and cardiovascular risk modification, including in people without diabetes

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Figure 3 According to the OGTT at the beginning of the study (timepoint 1), 21 women had normal glucose tolerance (NGT), 3 had impaired fasting glucose (IFG), and 1 had impaired glucose tolerance (IGT)

Natriuresis: Another way in which water loss happens with GLP-1 drugs is natriuresis, where the kidneys discrete too much sodium