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Adipose tissue NAD+ levels increased by 4055%, with corresponding upregulation of genes involved in fatty acid oxidation (CPT1, ACOX1) and mitochondrial respiration (PGC-1)

The compound may work synergistically with NAD+ precursors like NMN or NR, potentially enhancing metabolic benefits

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This visual assessment is supported by a statistical 2 -test, where the cost of the model ( v * for the optimal cost, see Methods ), given the optimal parameter values ( * , see Table S2), is below the threshold of rejection given by the 2 -test ( v * = 130.8 2

Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure