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In addition, detailed mechanistic studies are necessary to elucidate the specific pathways through which GLP-1R agonists exert their analgesic effects, independent of weight loss and metabolic improvements
Arrowhead Pharmaceuticals, for example, is developing RNA-based therapies that silence specific genes expressed in the liver and adipocytes
Specifically, this study revealed that patients taking these drugs had three times the risk of stomach paralysis and a nine-fold increase in pancreatitis compared to those using other weight loss medications
Risk factors include smoking, high blood pressure, high cholesterol, diabetes, and being over age 50
Li L, Shen J, Bala MM, Busse JW, Ebrahim S, Vandvik PO, et al
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