Barton-Davis, E.R., Shoturma, D.I
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When activated, mast cells release a cascade of inflammatory mediators, including: This can disrupt the BBB, promote leukocyte infiltration, and create a pro-inflammatory CNS microenvironment
A medical provider evaluation is required before prescriptions are issued
However, further research is needed to fully understand how these therapies exert their effect on body weight and in the last section we cover open questions about the potential mechanisms of multiagonist drugs, and the understanding of how gutbrain communication can be leveraged to achieve sustained body weight loss without adverse effects