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Botch protects neurons from ischemic insult by antagonizing Notch-mediated neuroinflammation

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Glutathione plays a crucial role in regulating melanin production, resulting in skin whitening

Additionally, the SARS-CoV-2 nucleocapsid (N) protein physically binds Smad3 to promote its phosphorylation and nuclear translocation, thereby triggering the Smad3-RIPK3-MLKL pathway to induce severe tubular necroptosis and kidney injury in diabetic models (138)