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However, more recent evidence suggests that sustained supplementation at moderate doses may modestly raise levels over time

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Restraints High Cost and Potential Gastrointestinal Side Effects May Restrain Market Growth The relatively high cost of GLP-1 receptor agonists can be a significant restraint on market growth, particularly in regions with limited healthcare access or reimbursement

Firstly, there is an urgent need for extended follow-up studies that last longer than current trial lengths to assess the long-term safety and efficacy of therapies over a decade or more

To this end, RGA developed a model to assess the potential impact of these drugs as treatments for weight loss in obese populations, and for diabetes on population mortality and morbidity, revealing significant potential reductions in cardiovascular incidence and mortality rates